Cocaine Addiction

Cocaine is a white powdery substance that can be snorted (coke), smoked (freebasing) or dissolved in water and injected into a vein (crack). It acts on the central nervous system to produce energy and euphoria. Some people experience addiction to cocaine, which is a drug use disorder.Go here

Long-term cocaine use may lead to problems with family, work and health. It can cause a variety of physical issues, such as damage to nasal passages from snorting and dental problems from drug-related clenching or grinding of the teeth. It can also affect the heart, lungs and brain. It is a major cause of drug-related death. It can also increase a person’s risk of infection, particularly from hepatitis C or HIV from sharing needles.

The Science Behind Cocaine Addiction: How It Affects the Brain

People who use cocaine can develop a tolerance, meaning they have to take higher doses to get the same high. Some people may also develop a sensitivity to the drug, known as sensitization. This means that even tiny amounts can produce negative effects such as anxiety, convulsions or a feeling of intense cravings.

Researchers have found that cocaine affects several genes in the brain. It increases the production of a chemical called DFosB, which has the same effect on the brain as dopamine but is much more long-lasting. DFosB influences how the brain releases other chemicals, including the neurotransmitter glutamate. This makes the brain more sensitive to cocaine’s positive rewards and reinforces drug use. It also increases the likelihood of developing an addictive disorder.